Concise Review: Pax6 Transcription Factor Contributes to both Embryonic and Adult Neurogenesis as a Multifunctional Regulator
Article first published online: 8 MAY 2008
Copyright © 2008 AlphaMed Press
Volume 26, Issue 7, pages 1663–1672, July 2008
How to Cite
Osumi, N., Shinohara, H., Numayama-Tsuruta, K. and Maekawa, M. (2008), Concise Review: Pax6 Transcription Factor Contributes to both Embryonic and Adult Neurogenesis as a Multifunctional Regulator. STEM CELLS, 26: 1663–1672. doi: 10.1634/stemcells.2007-0884
- Issue published online: 2 JAN 2009
- Article first published online: 8 MAY 2008
- Manuscript Accepted: 10 APR 2008
- Manuscript Received: 20 OCT 2007
- Embryonic neurogenesis;
- Adult neurogenesis;
- Pax6 transcription factor;
- Neural stem cells;
Pax6 is a highly conserved transcription factor among vertebrates and is important in various developmental processes in the central nervous system (CNS), including patterning of the neural tube, migration of neurons, and formation of neural circuits. In this review, we focus on the role of Pax6 in embryonic and postnatal neurogenesis, namely, production of new neurons from neural stem/progenitor cells, because Pax6 is intensely expressed in these cells from the initial stage of CNS development and in neurogenic niches (the subgranular zone of the hippocampal dentate gyrus and the subventricular zone of the lateral ventricle) throughout life. Pax6 is a multifunctional player regulating proliferation and differentiation through the control of expression of different downstream molecules in a highly context-dependent manner.
Disclosure of potential conflicts of interest is found at the end of this article.