research-article
You have full text access to this OnlineOpen article
Direct Orthotopic Transplantation of Fresh Surgical Specimen Preserves CD133+ Tumor Cells in Clinically Relevant Mouse Models of Medulloblastoma and Glioma
Article first published online: 10 APR 2008
DOI: 10.1634/stemcells.2007-1009
Copyright © 2008 AlphaMed Press
Additional Information
How to Cite
Shu, Q., Wong, K. K., Su, J. M., Adesina, A. M., Yu, L. T., Tsang, Y. T. M., Antalffy, B. C., Baxter, P., Perlaky, L., Yang, J., Dauser, R. C., Chintagumpala, M., Blaney, S. M., Lau, C. C. and Li, X.-N. (2008), Direct Orthotopic Transplantation of Fresh Surgical Specimen Preserves CD133+ Tumor Cells in Clinically Relevant Mouse Models of Medulloblastoma and Glioma. STEM CELLS, 26: 1414–1424. doi: 10.1634/stemcells.2007-1009
Publication History
- Issue published online: 2 JAN 2009
- Article first published online: 10 APR 2008
- Manuscript Accepted: 24 MAR 2008
- Manuscript Received: 29 NOV 2007
References
- 1, , et al. White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumor. J Clin Oncol 2004; 22:4551–4560.
- 2, , et al. Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma. J Neurooncol 2005; 72:245–253.
- 3
- 4, , et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006; 9:157–173.
- 5, . Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist. Oncologist 2004; 9:197–206.
- 6, , et al. Stem cells, cancer, and cancer stem cells. Nature 2001; 414:105–111.
- 7, , et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A 2003; 100:15178–15183.
- 8, , et al. Identification of human brain tumour initiating cells. Nature 2004; 432:396–401.
- 9, , et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63:5821–5828.
- 10, , et al. Cancer stem cells in nervous system tumors. Oncogene 2004; 23:7267–7273.
- 11, , et al. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol 2004; 5:738–743.
- 12, , et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003; 100:3983–3988.
- 13. Epithelial stem cells in human prostate growth and disease. Prostate Cancer Prostatic Dis 2004; 7:188–194.
- 14, , et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004; 64:7011–7021.
- 15, , et al. Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 2004; 23:9392–9400.
- 16, , et al. Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A 2000; 97:14720–14725.
- 17, , et al. Tumour stem cells and drug resistance. Nat Rev Cancer 2005; 5:275–284.
- 18, , et al. Cancer stem cells: are we missing the target? J Natl Cancer Inst 2004; 96:583–585.
- 19, . Successful therapy must eradicate cancer stem cells. Stem Cells 2006; 24:2603–2610.
- 20, , et al. Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors. Cancer Res 2007; 67:3560–3564.
- 21, , et al. Radiation resistance and stem-like cells in brain tumors. Cancer Cell 2006; 10:454–456.
- 22, , et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444:756–760.
- 23
- 24, . Mouse models of brain tumors and their applications in preclinical trials. Clin Cancer Res 2006; 12:5288–5297.
- 25, . 50 years of preclinical anticancer drug screening: empirical to target-driven approaches. Clin Cancer Res 2005; 11:971–981.
- 26, , et al. Histological characteristics and expression of acidic and basic fibroblast growth factor genes in intracerebral xenogeneic transplants of human glioma cells. Neurosurgery 1994; 34:136–143.
- 27, , et al. In vitro and in vivo models for the study of brain tumour invasion. Anticancer Res 1997; 17:4107–4109.
- 28, , et al. Intracerebral transplantation of a human glioma line in immunosuppressed rats. J Neurosurg 1984; 60:582–588.
- 29. Model systems in neurooncology. Acta Neurochir Suppl 2002; 83:79–83.
- 30, , et al. A model for human medulloblastoma. Growth, morphology, and chromosomal analysis in vitro and in athymic mice. J Neuropathol Exp Neurol 1983; 42:485–503.
- 31. Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Invest New Drugs 1999; 17:343–359.
- 32, , et al. Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res 2006; 66:4215–4222.
- 33, , et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006; 9:391–403.
- 34
- 35, , et al. Neuronal and glial proteins in medulloblastomas. II. Heterotransplantation of human medulloblastoma. Anticancer Res 1986; 6:911–915.
- 36, . The role of xenografting in pediatric brain tumor research with specific emphasis on medulloblastoma/primitive neuroectodermal tumors of childhood. In Vivo 2003; 17:329–342.
- 37
- 38, . Normal stem cells and cancer stem cells: the niche matters. Cancer Res 2006; 66:4553–4557.
- 39, , et al. Stem cells, cancer, and context dependence. Stem Cells 2007; 26:292–298.Direct Link:
- 40, , et al. Valproic acid prolongs survival time of severe combined imunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. Clin Cancer Res 2006; 12:4687–4694.
- 41, , et al. Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array. Cancer Res 2006; 66:11172–11178.
- 42, , et al. Neurosphere assays: growth factors and hormone differences in tumor and nontumor studies. Stem Cells 2006; 24:2851–2857.
- 43, , et al. Disrupting tumour blood vessels. Nat Rev Cancer 2005; 5:423–435.
- 44, , et al. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol 1999; 155:739–752.
- 45, , et al. Isolation and characterization of human breast tumor-derived endothelial cells. Oncol Rep 2006; 15:381–386.
- 46, , et al. Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer. Cell Tissue Res 2005; 319:15–26.
- 47, , et al. CD133, a novel marker for human prostatic epithelial stem cells. J Cell Sci 2004; 117:3539–3545.
- 48, , et al. Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis. Cancer Res 2007; 67:32–40.
- 49, , et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999; 284:1994–1998.
- 50, , et al. Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis. Lab Invest 2000; 80:837–849.
- 51, , et al. Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proc Natl Acad Sci U S A 2006; 103:16466–16471.
- 52
- 53, . Glioblastoma cells do not intravasate into blood vessels. Neurosurgery 1995; 36:124–132.
- 54, , et al. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2000; 2:306–314.
- 55, , et al. Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, Vegf receptor-2, and angiopoietin-2. J Clin Invest 2002; 109:777–785.

1549-4918/asset/olbannerleft.jpg?v=1&s=699114e871887e6b838f6a1c657fe256cfe127a6)
1549-4918/asset/olbannerright.gif?v=1&s=603f8f2ab5cd9d4f783c231915608956af51aeea)
1549-4918/asset/cover.gif?v=1&s=51ac62b4272cd760b70f0cb1539035cc40743da6)