Olfactory Mucosa Is a Potential Source for Autologous Stem Cell Therapy for Parkinson's Disease

Authors

  • Wayne Murrell B.Sc. (Hons), Ph.D.,

    Corresponding author
    1. National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
    • Vilhelm Magnus Center, Institute for Surgical Research, Rikshospital, University of Oslo, Oslo, Norway 0027. Telephone: 47-23071405; Fax: 47-23071397
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  • Andrew Wetzig,

    1. National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
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  • Michael Donnellan,

    1. National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
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  • François Féron,

    1. NICN, CNRS UMR6184, IFR Jean Roche & Centre d'Investigations Cliniques en Biothérapie CIC-B 150, AP-HM-Institut Paoli Calmettes-Inserm, Université de la Méditerranée, Marseille, France
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  • Tom Burne,

    1. National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
    2. School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia
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  • Adrian Meedeniya,

    1. National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
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  • James Kesby,

    1. School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia
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  • John Bianco,

    1. National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
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  • Chris Perry,

    1. Department of Otolaryngology, Princess Alexandra Hospital, Brisbane, Australia
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  • Peter Silburn,

    1. National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
    2. School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
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  • Alan Mackay-Sim

    1. National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
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Abstract

Parkinson's disease is a complex disorder characterized by degeneration of dopaminergic neurons in the substantia nigra in the brain. Stem cell transplantation is aimed at replacing dopaminergic neurons because the most successful drug therapies affect these neurons and their synaptic targets. We show here that neural progenitors can be grown from the olfactory organ of humans, including those with Parkinson's disease. These neural progenitors proliferated and generated dopaminergic cells in vitro. They also generated dopaminergic cells when transplanted into the brain and reduced the behavioral asymmetry induced by ablation of the dopaminergic neurons in the rat model of Parkinson's disease. Our results indicate that Parkinson's patients could provide their own source of neuronal progenitors for cell transplantation therapies and for direct investigation of the biology and treatments of Parkinson's disease.

Disclosure of potential conflicts of interest is found at the end of this article.

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