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Tissue-Specific Stem Cells
Article first published online: 5 JAN 2009
Copyright © 2008 AlphaMed Press
Volume 27, Issue 1, pages 259–265, January 2009
How to Cite
Cho, K.-S., Park, H.-K., Park, H.-Y., Jung, J. S., Jeon, S.-G., Kim, Y.-K. and Roh, H. J. (2009), IFATS Collection: Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells in an Allergic Rhinitis Mouse Model. STEM CELLS, 27: 259–265. doi: 10.1634/stemcells.2008-0283
Author contributions: K.S.C.: collection and/or assembly of data, manuscript writing, data analysis and interpretation; H.K.P.: Collection and/or assembly of data, data analysis and interpretation; H.Y.P.: collection and/or assembly of data; J.S.J.: provision of study material or patients; S.G.J.: data analysis and interpretation; Y.K.K.: provision of study material or patients; H.J.R.: conception and design.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLSExpress October 2, 2008.
- Issue published online: 5 JAN 2009
- Article first published online: 5 JAN 2009
- Manuscript Accepted: 22 SEP 2008
- Manuscript Received: 19 MAR 2008
- Adipose tissue;
- Stem cells;
- Allergic rhinitis
Adipose tissue-derived stem cells (ASCs) exhibit immunosuppressive effects in allogeneic transplantation. However, there is no report that evaluates the in vivo immune-modulating effect of ASCs in an experimental allergic rhinitis (AR) model. We investigated whether ASCs migrate to the nasal mucosa in an AR mouse model and evaluated the immune-modulating effect of ASCs in the AR mouse model. Cultured ASCs (2 × 106) were injected i.v. before the first allergen challenge in the AR mouse model. Migration of ASCs to the nasal mucosa was evaluated by immunofluorescence. The immunomodulatory effects of ASCs were evaluated by nasal symptoms, histology, serum ovalbumin (OVA)-specific antibody, and the cytokine profile of the spleen. ASCs migrated to the nasal mucosa in the AR mouse model. ASCs significantly reduced allergic symptoms and inhibited eosinophilic inflammation in the nasal mucosa. ASCs significantly decreased the serum allergen-specific IgE level and the IgG1/IgG2a ratio and significantly increased the IgG2a level in the AR mouse model. ASCs inhibited interleukin (IL)-4 and IL-5 production from OVA-incubated splenocytes, but enhanced interferon-γ production. In conclusion, ASCs can migrate to the nasal mucosa in the AR mouse model and inhibit eosinophilic inflammation partly via shifting to a T-helper 1 (Th1) from a Th2 immune response to allergens. STEM CELLS2009;27:259–265