Regulatory Issues for Personalized Pluripotent Cells
Article first published online: 31 JUL 2008
Copyright © 2008 AlphaMed Press
Volume 26, Issue 11, pages 2753–2758, November 2008
How to Cite
Condic, M. L. and Rao, M. (2008), Regulatory Issues for Personalized Pluripotent Cells. STEM CELLS, 26: 2753–2758. doi: 10.1634/stemcells.2008-0421
- Issue published online: 9 JAN 2009
- Article first published online: 31 JUL 2008
- Manuscript Accepted: 17 JUL 2008
- Manuscript Received: 29 APR 2008
- Induced pluripotent stem cells;
- Embryonic stem cell;
- Somatic cell nuclear transfer;
The development of personalized pluripotent stem cells for research and for possible therapies holds out great hope for patients. However, such cells will face significant technical and regulatory challenges before they can be used as therapeutic reagents. Here we consider two possible sources of personalized pluripotent stem cells: embryonic stem cells derived from nuclear transfer (NT-ESCs) and induced pluripotent stem cells (iPSCs) derived from direct reprogramming of adult somatic cells. Both sources of personalized pluripotent stem cells face unique regulatory hurdles that are in some ways significantly higher than those facing stem cells derived from embryos produced by fertilization (ESCs). However, the outstanding long-term potential of iPSCs and their relative freedom from the ethical concerns raised by both ESCs and NT-ESCs makes direct reprogramming an exceptionally promising approach to advancing research and providing therapies in the field of regenerative medicine.
Disclosure of potential conflicts of interest is found at the end of this article.