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Embryonic Stem Cells/Induced Pluripotent Stem Cells
Version of Record online: 5 JAN 2009
Copyright © 2008 AlphaMed Press
Volume 27, Issue 1, pages 78–87, January 2009
How to Cite
Erceg, S., Ronaghi, M. and Stojković, M. (2009), Human Embryonic Stem Cell Differentiation Toward Regional Specific Neural Precursors. STEM CELLS, 27: 78–87. doi: 10.1634/stemcells.2008-0543
Author contributions: S.E.: conception and design, manuscript writing; M.R.: conception and design, manuscript writing; S.E. and M.R. contributed equally to this work; M.S.: conception and design, manuscript writing, financial support, final approval of manuscript.
Disclosure of potential conflicts of interest is found at the end of this article.
First published online in STEM CELLSExpress October 9, 2008; available online without subscription through the open access option.
- Issue online: 5 JAN 2009
- Version of Record online: 5 JAN 2009
- Manuscript Accepted: 30 SEP 2008
- Manuscript Received: 6 JUN 2008
- Regional Government Health Department (Generalitat Valenciana)
- Instituto Carlos III belonging to the Spanish Ministry of Health and Consumer Affairs
- Spanish Ministry of Education and Science. Grant Number: SAF2007–63714
- Human embryonic stem cells;
- Neural differentiation;
- Cell culture;
- Cellular therapy
Human embryonic stem cells (hESCs) are self-renewing pluripotent cells that have the capacity to differentiate into a wide variety of cell types. This potentiality represents a promising source to overcome many human diseases by providing an unlimited supply of all cell types, including cells with neural characteristics. Therefore, this review summarizes early neural development and the potential of hESCs to differentiate under in vitro conditions, examining at the same time the potential use of differentiated hESCs for therapeutic applications for neural tissue and cell regeneration. STEM CELLS2009;27:78–87