Great Lakes Environmental Research Laboratory Contribution 1282.
Time-dependent lethal body residues for the toxicity of pentachlorobenzene to Hyalella azteca†
Article first published online: 5 NOV 2009
Copyright © 2004 SETAC
Environmental Toxicology and Chemistry
Volume 23, Issue 5, pages 1335–1343, May 2004
How to Cite
Landrum, P. F., Steevens, J. A., Gossiaux, D. C., McElroy, M., Robinson, S., Begnoche, L., Chernyak, S. and Hickey, J. (2004), Time-dependent lethal body residues for the toxicity of pentachlorobenzene to Hyalella azteca. Environmental Toxicology and Chemistry, 23: 1335–1343. doi: 10.1897/03-164
- Issue published online: 5 NOV 2009
- Article first published online: 5 NOV 2009
- Manuscript Accepted: 13 SEP 2003
- Manuscript Received: 19 MAR 2003
- Lethal body residue;
- Hyalella azteca;
- Temporal trends
The study examined the temporal response of Hyalella azteca to pentachlorobenzene (PCBZ) in water-only exposures. Toxicity was evaluated by calculating the body residue of PCBZ associated with survival. The concentration of PCBZ in the tissues of H. azteca associated with 50% mortality decreased from 3 to 0.5 μmol/g over the temporal range of 1 to 28 d, respectively. No significant difference was observed in the body residue calculated for 50% mortality when the value was determined using live or dead organisms. Metabolism of PCBZ was not responsible for the temporal response because no detectable PCBZ biotransformation occurred over an exposure period of 10 d. A damage assessment model was used to evaluate the impact and repair of damage by PCBZ on H. azteca. The toxicokinetics were determined so that the temporal toxicity data could be fit to a damage assessment model. The half-life calculated for the elimination of PCBZ averaged approximately 49 h, while the value determined for the half-life of damage repair from the damage assessment model was 33 h.