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Pour-on formulation of eprinomectin for cattle: Fecal elimination profile and effects on the development of the dung-inhabiting Diptera Neomyia cornicina (L.) (Muscidae)

Authors

  • Jean-Pierre Lumaret,

    Corresponding author
    1. UMR 5175 CEFE (Centre d'Ecologie Fonctionnelle et Evolutive), Laboratoire de Zoogeographie, Universite Paul Valery-Montpellier III, Route de Mende, F-34199 Montpellier Cedex 5, France
    • UMR 5175 CEFE (Centre d'Ecologie Fonctionnelle et Evolutive), Laboratoire de Zoogeographie, Universite Paul Valery-Montpellier III, Route de Mende, F-34199 Montpellier Cedex 5, France
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  • Faiek Errouissi,

    1. Unite de recherche Biologie et Ecologie Animale, ISSBAT, 9 ave Zohaïr ESEFFI (ex-faculte de Medecine de Tunis) Université de Tunis II, 1007 Tunis, Tunisia
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  • Pierre Galtier,

    1. Laboratoire de Pharmacologie et Toxicologie, INRA-UR66, 180 Chemin de Tournefeuille, F-31931 Toulouse Cedex, France
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  • Michel Alvinerie

    1. Laboratoire de Pharmacologie et Toxicologie, INRA-UR66, 180 Chemin de Tournefeuille, F-31931 Toulouse Cedex, France
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Abstract

The plasma and fecal concentrations ofeprinomectin weredetermined in cattlefollowing topical administrationat a dose rate of 0.5 mg kg−1. The maximum plasma concentrations of 12.24 ng ml−1 occurred 2 d after administration, and eprinomectin remained detectable in plasma 29 d after administration (0.10 ng ml−1). The maximum dung concentration of 350 ng g−1 was observed 3 d after administration and thereafter for at least 29 d (4 ng g−1). The amount of drug recovered in dung during this period was 20.50% ± 4.31% of the total administered dose. The effects of eprinomectin against the nontarget dung-feeding Diptera Neomyia cornicina was assessed under laboratory conditions. Feces voided by cattle treated with eprinomectin were associated with high larval mortality during the first 12 d after treatment, with null emergence until day 7. The no-observed-effect concentration for N. cornicina was estimated to be close to 7 ± 5 ng g−1.

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