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Determination of select antidepressants in fish from an effluent-dominated stream

Authors

  • Bryan W. Brooks,

    Corresponding author
    1. Department of Environmental Studies, Baylor University, Waco, Texas 76798, USA
    2. Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, Texas 76798, USA
    • Department of Environmental Studies, Baylor University, Waco, Texas 76798, USA
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  • C. Kevin Chambliss,

    1. Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, Texas 76798, USA
    2. Department of Chemistry and Biochemistry, Baylor University, Waco, Texas 76798, USA
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  • Jacob K. Stanley,

    1. Department of Chemistry and Biochemistry, Baylor University, Waco, Texas 76798, USA
    2. Department of Biology, Baylor University, Waco, Texas 76798, USA
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  • Alejandro Ramirez,

    1. Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, Texas 76798, USA
    2. Department of Chemistry and Biochemistry, Baylor University, Waco, Texas 76798, USA
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  • Kenneth E. Banks,

    1. Watershed Resources Program, City of Denton, Denton, Texas 76209, USA
    2. Institute of Applied Sciences, University of North Texas, Denton, Texas 76205, USA
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  • Robert D. Johnson,

    1. Civil Aerospace Medical Institute, Federal Avation Administration, Oklahoma City, Oklahoma 73125, USA
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  • Russell J. Lewis

    1. Civil Aerospace Medical Institute, Federal Avation Administration, Oklahoma City, Oklahoma 73125, USA
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Abstract

Increasing evidence indicates widespread occurrence of pharmaceuticals and personal care products (PPCPs) in municipal effluent discharges and surface waters. Studies that characterize the fate and effects of PPCPs in aquatic systems are limited, and to our knowledge, data regarding pharmaceutical accumulation in fish of effluent-dominated ecosystems have not been previously reported. In the present study, fish populations were sampled from a reference stream and an effluent-dominated stream in north Texas, USA. Lepomis macrochirus, Ictalurus punctatus, Cyprinus carpio, and Pomoxis nigromaculatus were killed; the liver, brain, and lateral filet tissues dissected; and the tissues stored at −80°C until analysis. Fish tissues were extracted using solid-phase extraction and then analyzed by gas chromatography-mass spectrometry in the negative chemical ionization mode. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline and the SSRI metabolites norfluoxetine and desmethylsertraline were detected at levels greater than 0.1 ng/g in all tissues examined from fish residing in a municipal effluent-dominated stream. To our knowledge, the present study is the first report of SSRI residues in fish residing within municipal effluent-dominated systems.

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