Published on the Web 2/2/2009.
Environmental Toxicology
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Effluent from bulk drug production is toxic to aquatic vertebrates†
Article first published online: 6 JAN 2010
DOI: 10.1897/08-524.1
Copyright © 2009 SETAC
Additional Information
How to Cite
Carlsson, G., Örn, S. and Larsson, D. G. J. (2009), Effluent from bulk drug production is toxic to aquatic vertebrates. Environmental Toxicology and Chemistry, 28: 2656–2662. doi: 10.1897/08-524.1
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Publication History
- Issue published online: 6 JAN 2010
- Article first published online: 6 JAN 2010
- Manuscript Accepted: 29 JAN 2009
- Manuscript Received: 20 OCT 2008
REFERENCES
- 1, , , , . 2008. Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ Sci Technol 42: 5807–5813.
- 2, , , , , , , . 2008. Derivation of an aquatic predicted no-effect concentration for the synthetic hormone, 17α-ethinylestradiol. Environ Sci Technol 42: 7046–7054.
- 3, , , , , , , , , , , , . 2004. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 427: 630–633.
- 4, , , , , , , . 2007. Effects of the parasiticide ivermectin on the cladoceran Daphnia magna and the green alga Pseudokirchneriella subcapitata. Chemosphere 69: 903–910.
- 5. 2005. Human health pharmaceuticals in the environment—An introduction. In WilliamsRT, ed, Human Pharmaceuticals: Assessing the Impact on Aquatic Ecosystems. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, pp 1–46.
- 6. 2002. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: A review of recent research data. Toxicol Lett 131: 5–17.
- 7, , , , , , . 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999–2000: A national reconnaissance. Environ Sci Technol 36: 1202–1211.
- 8, . 2007. Exposure to pharmaceuticals present in the environment. Drug Inf J 41: 133–141.
- 9, , . 2007. Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater 148: 751–755.
- 10. 2008. Drug production facilities—An overlooked discharge source for pharmaceuticals to the environment. In KümmererK, ed, Pharmaceuticals in the Environment: Sources, Fate, Effects, and Risks. Springer, New York, NY, USA, pp 37–42.
- 11, , , , , . 2008. Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and the receiving river. Environ Toxicol Chem 27: 80–86.
- 12. 2008. Antibiotics and antibiotic resistance genes in natural environments. Science 321: 365–367.
- 13, . 1994. Testing acute toxicity in the embryo of zebrafish, Brachydanio rerio, as an alternative to the acute fish test: Preliminary results. ATLA Altern Lab Anim 20: 12–19.
- 14, . 2004. Synthetic musk toxicity to early life stages of zebrafish (Danio rerio). Arch Environ Contam Toxicol 46: 102–105.
- 15, , , , , . 2005. Assessing contamination levels of Laguna Lake sediments (Philippines) using a contact assay with zebrafish (Danio rerio) embryos. Sci Total Environ 347: 254–271.
- 16, , , , , , , . 2005. Towards an alternative for the acute fish LC50 test in chemical assessment: The fish embryo toxicity test goes multi-species—An update. ALTEX 22: 87–102.
- 17, , , , , . 2005. Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine. Toxicol Sci 87: 353–364.
- 18, , , , , , , . 2005. Metamorphic inhibition of Xenopus laevis by sodium perchlorate: Effects on development and thyroid histology. Environ Toxicol Chem 24: 926–933.
- 19, , , , , , , , , , . 2006. Development of metamorphosis assay using Silurana tropicalis for the detection of thyroid system-disrupting chemicals. Ecotoxicol Environ Saf 64: 281–287.
- 20, . 2007. The impact of the goitrogen 6-propylthiouracil (PTU) on West-African clawed frog (Xenopus tropicalis) exposed during metamorphosis. Aquat Toxicol 82: 55–62.
- 21, , , . 2007. Distribution of BDE-99 and effects on metamorphosis of BDE-99 and −47 after oral exposure inXenopus tropicalis. Aquat Toxicol 84: 71–79.
- 22, , , , . 2006. Persistent sex-reversal and oviducal agenesis in adult Xenopus (Silurana) tropicalis frogs following larval exposure to the environmental pollutant ethynylestradiol. Aquat Toxicol 79: 356–365.
- 23, . 1994. Normal Table of Xenopus laevis. Garland, New York, NY, USA.
- 24International Organization for Standardization. 1996. Water quality—Determination of the acute lethal toxicity of substances to a freshwater fish [Brachydanio rerio Hamilton-Buchanan (Teleostei, Cyprinidae)] Part 1: Static method. ISO 7346–1:1996. Geneva, Switzerland.
- 25, , , , , . 2009. Contamination of surface, ground, and drinking water from pharmaceutical production. Environ Toxicol Chem 28: 2522–2527.
- 26, , . 2000. Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test. Chemosphere 40: 701–710.
- 27, . 2006. A toxicity and hazard assessment of fourteen pharmaceuticals to Xenopus laevis larvae. Ecotoxicology 15: 647–656.
- 28, , , . 2000. Environmental risk assessment of antibiotics: comparison of mecillinam, trimethoprim and ciprofloxacin. J Antimicrob Chemother 46(Suppl. 1):53–58.
- 29, , . 2005. Toxicity of fluoroquinolone antibiotics to aquatic organisms. Environ Toxicol Chem 24: 423–430.
- 30, , , , . 2002. Toxicity of select beta adrenergic receptor-blocking pharmaceuticals (β-blockers) on aquatic organisms. Arch Environ Contam Toxicol 43: 229–235.
- 31, , , . 2007. Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio). Anal Bioanal Chem 387: 1405–1416.
- 32, , , , . 2006. Is heart rate in fish a sensitive indicator to evaluate acute effects of β-blockers in surface water?. Environ Toxicol Pharmacol 22: 338–340.
- 33. 2002. DarT: The embryo test with the zebrafish Danio rerio—A general model in ecotoxicology and toxicology. ALTEX 19: 38–48.
- 34, , , . 2007. Enantiospecific sublethal effects of the antidepressant fluoxetine to a model aquatic vertebrate and invertebrate. Chemosphere 69: 9–16.
- 35, , . 2007. [3H] Citalopram binding to serotonin transporter sites in minnow brains. Basic and Clinical Pharmacology and Toxicology 101: 203–210.
- 36, , . 2001. Angiotensin signaling and receptor types in teleost fish. Comp Biochem Physiol A Mol Integr Physiol 128: 41–51.
- 37, , , , , . 2006. Evaluation of histological and molecular endpoints for enhanced detection of thyroid system disruption in Xenopus laevis tadpoles. Toxicol Sci 90: 337–348.
- 38. 2006. Amphibian metamorphosis as a model for the developmental actions of thyroid hormone. Mol Cell Endocrinol 246: 10–20.
- 39, , . 2006. Development of a zebrafish 4-day embryo-larval bioassay to assess toxicity of chemicals. Ecotoxicol Environ Saf 63: 253–267.
- 40, . 2009. Transparency throughout the production chain—A way to reduce pollution from the manufacturing of pharmaceuticals?. Regul Toxicol Pharmacol 53: 161–163.

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