Published on the Web 4/7/2008.
An assessment of endocrine disruption in mollusks and the potential for developing internationally standardized mollusk life cycle test guidelines†
Article first published online: 5 NOV 2009
Copyright © 2008 SETAC
Integrated Environmental Assessment and Management
Volume 4, Issue 3, pages 274–284, July 2008
How to Cite
Matthiessen, P. (2008), An assessment of endocrine disruption in mollusks and the potential for developing internationally standardized mollusk life cycle test guidelines. Integr Environ Assess Manag, 4: 274–284. doi: 10.1897/IEAM_2008-003.1
- Issue published online: 5 NOV 2009
- Article first published online: 5 NOV 2009
- Manuscript Accepted: 16 MAR 2008
- Manuscript Received: 9 JAN 2008
- Endocrine disruptor;
- Life cycle testing
This paper summarizes what is known about the endocrine systems of mollusks and how they can be disrupted by exogenous substances. It then examines the various possibilities for using mollusk-based toxicity tests to detect and assess the environmental risks of endocrine-disrupting chemicals (EDCs). It is concluded that there are no internationally standardized tests with mollusks available at present that are suitable for assessing the risks of long-term exposure to EDCs but that several published methods show potential. At the present state of knowledge, the most promising mollusk species for use in partial life cycle testing is probably the fresh- and brackish-water mesogastropod, Potamopyrgus antipodarum, which is known to be responsive to both direct and indirect androgens and to estrogens (and their mimics). Less experience of full life cycle testing exists with mollusks, but the freshwater pulmonate gastropod Lymnaea stagnalis at present offers the best possibility for a practical procedure. In both cases, there is a need for substantial test optimization and validation before these procedures could form the basis of international guidelines.