Transportation has contributed in many ways to improve human life and well-being. From humanitarian assistance to rapid sharing, food and pharmaceutical transportation does benefit mankind in ways that are not always appreciated. Unfortunately, transportation can negatively impact human health in two broad ways: accidents and environmental pollution. It can also facilitate the spread of infectious diseases. Safe and responsible use of transportation technology is of concern to all users, operators, and technologists, including healthcare providers. Medical professionals should participate in safety and educational campaigns, bioengineering and human factors research, and advocacy of the timely introduction of health and safety policies for a more responsible operation of transportation and new technology insertion.