Pharmacokinetics of imidocarb dipropionate in horses after intramuscular administration

Authors

  • C. BELLOLI,

    Corresponding author
    1. Department of Animal Health and Welfare (Veterinary Pharmacology and Toxicology), University of Bari - Strada Provinciate per Casamassima km 3, 70010 - Valenzano (BA), Italy
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  • G. CRESCENZO,

    1. Department of Animal Health and Welfare (Veterinary Pharmacology and Toxicology), University of Bari - Strada Provinciate per Casamassima km 3, 70010 - Valenzano (BA), Italy
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  • O. LAI,

    1. Department of Animal Health and Welfare (Veterinary Pharmacology and Toxicology), University of Bari - Strada Provinciate per Casamassima km 3, 70010 - Valenzano (BA), Italy
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  • V. CAROFIGLIO,

    1. Department of Animal Health and Welfare (Veterinary Pharmacology and Toxicology), University of Bari - Strada Provinciate per Casamassima km 3, 70010 - Valenzano (BA), Italy
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  • O. MARANG,

    1. Veterinary practitioner, via Comiteo 74, 74012 - Crispiano (TA), Italy
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  • P. ORMAS

    1. Department of Animal Health and Welfare (Veterinary Pharmacology and Toxicology), University of Bari - Strada Provinciate per Casamassima km 3, 70010 - Valenzano (BA), Italy
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Department of Animal Health and Welfare (Veterinary Pharmacology and Toxicology), University of Bari - Strada Provinciate per Casamassima km 3, 70010 - Valenzano (BA), Italy

Summary

The objective of this study was to determine the pharmacokinetic behaviourof imidocarb in horses following a single i.m. injection at the dose commonly administered to treat Babesia caballi infections or to prevent babesiosis. Eight horses were injected i.m. with a single dose of 2.4 mg imidocarb dipropionate/kg bwt and blood, faecal, urine and milk samples were collected.

For imidocarb determination, a high-performance liquid chromatographic method (HPLC) was used afterweak cation-exchange solid phase, or liquid-liquid, extraction procedures. Twelve hours after treatment, no detectable plasma concentrations were recorded in any of the treated animals. The distribution and elimination patterns of the drug suggested that it is quickly sequestrated in some storage tissues and remains in the body for a long time. Its prolonged presence in the body may confer a reservoir effect to imidocarb in some tissues, therefore making it undetectable in the plasma of animals but sufficient to produce its described therapeutic and prophylactic activities.

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