Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, PO Box College Station, Texas 77843, USA.
Evaluation of Carolina Rinse solution as a treatment for ischaemia reperfusion of the equine jejunum
Article first published online: 5 JAN 2010
2003 EVJ Ltd
Equine Veterinary Journal
Volume 35, Issue 7, pages 642–646, November 2003
How to Cite
Dabareiner, R. M., II, N. A. W. and Donaldson, L. (2003), Evaluation of Carolina Rinse solution as a treatment for ischaemia reperfusion of the equine jejunum. Equine Veterinary Journal, 35: 642–646. doi: 10.2746/042516403775696302
- Issue published online: 5 JAN 2010
- Article first published online: 5 JAN 2010
- Paper received for publication 25.03.02; Accepted 23.12.02
- Carolina Rinse solution;
Reasons for performing study: Ileus and peritoneal adhesions are the most common complications following surgery for small intestinal obstruction. Carolina Rinse (CR) has been shown to decrease reperfusion injury in intestine and other organs.
Hypothesis: CR decreases intestinal inflammation and subsequent scarring associated with reperfusion injury.
Methods: CR was infused intra-arterially and applied topically just prior to reperfusion in jejunum exposed to experimental ischemia. Vascular permeability, neutrophil accumulation and serosal scarring were compared in treated and untreated intestine.
Resultls: CR maintained a normal osmotic reflection coefficient and decreased migration of neutrophils into the serosa during reperfusion. After 10 days, treated intestine was normal in appearance with a trend toward less serosal scarring and fibroblast proliferation. There was a significant decrease in fibroplasia at biopsy sites in treated intestine.
Conclusions: Arterial perfusion combined with topical application of CR during jejunal ischaemia decreases immediate reperfusion injury and limits post operative scarring.
Potential relevance: CR should be used as a local perfusate rather than a systemic treatment; it may best be applied topically and intraluminally to avoid damaging mesenteric arteries. CR should be considered an adjunct treatment as part of overall surgical management and post operative care.