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Management of drug-resistant cyathostominosis on a breeding farm in central North Carolina

  1. D. LITTLE1,
  2. J. R. FLOWERS2,
  3. B. H. HAMMERBERG2,
  4. S. Y. GARDNER1,*

Article first published online: 5 JAN 2010

DOI: 10.2746/042516403776148264

Issue

Equine Veterinary Journal

Equine Veterinary Journal

Volume 35, Issue 3, pages 246–251, May 2003

Additional Information

How to Cite

LITTLE, D., FLOWERS, J. R., HAMMERBERG, B. H. and GARDNER, S. Y. (2003), Management of drug-resistant cyathostominosis on a breeding farm in central North Carolina. Equine Veterinary Journal, 35: 246–251. doi: 10.2746/042516403776148264

Author Information

  1. 1

    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA

  2. 2

    Microbiology, Pathology and Parasitology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA

* Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA

Publication History

  1. Issue published online: 5 JAN 2010
  2. Article first published online: 5 JAN 2010
  3. [Paper received for publication 29.06.01; Accepted 11.07.02]

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Keywords:

  • horse;
  • cyathostome;
  • resistant;
  • benzimidazole;
  • pyrantel

Summary

Reasons for performing study: Possible anthelmintic resistance on a breeding farm where a rapid rotation anthelmintic programme had been implemented for 9 years was investigated. Cyathostomins resistant to fenbendazole and pyrantel were documented by faecal worm egg count reduction test (FWECRT).

Objectives: To 1) manage small strongyle transmission in a herd of horses in which resistance to both pyrantel pamoate and fenbendazole was identified and thereby reduce the risk of clinical disease in the individual animal, 2) monitor the change in resistance patterns over time and 3) monitor the efficacy of ivermectin over the study period.

Methods: Targeted ivermectin treatment of horses on the farm was instituted formature horses with faecal worm egg counts (FWEC) >200 eggs/g (epg) and for horses <age 2 years with FWEC >100 epg.

Results: Over a 30 month period, targeted ivermectin treatment achieved acceptable control in mares, as judged by FWEC, and improved control of patent cyathostome infection in consecutive foal crops. Egg reappearance time (ERT) after treatment with ivermectin was <8 weeks in mares and foals more frequently in the second year of the study than in the first year. Numbers of anthelmintic treatments were reduced by 77.6 and 53.3% in the mare and foal group, respectively.

Conclusions: Targeted ivermect in treatment may be an economically viable method of managing multiple drug resistant cyathostominosis.

Potential relevance: Use of ivermectin should be monitored closely for development of resistance.

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