Polyneuropathy of Finnish horses characterised by inflammatory demyelination and intracisternal Schwann cell inclusions
Article first published online: 5 JAN 2010
2008 EVJ Ltd
Equine Veterinary Journal
Volume 40, Issue 3, pages 231–236, May 2008
How to Cite
HAHN, C. N., MATIASEK, K., SYRJA, P., JOKINEN, T. S., MACINTYRE, N. and TULAMO, R. M. (2008), Polyneuropathy of Finnish horses characterised by inflammatory demyelination and intracisternal Schwann cell inclusions. Equine Veterinary Journal, 40: 231–236. doi: 10.2746/042516408X257574
- Issue published online: 5 JAN 2010
- Article first published online: 5 JAN 2010
- Paper received for publication 16.07.07, Accepted 22.10.07
- peripheral nervous system;
- Schwann cell;
- endoplasmatic reticulum
Reasons for performing study: A neurological disorder characterised by pelvic limb metatarsophalangeal joint extensor paresis has been observed in numerous horses in Scandinavia for the last decade. Very little has been formally reported and there have been no detailed assessments of the neurological signs or neuropathological lesions.
Objectives: To describe the epidemiological and pathological features of an outbreak of ‘Scandinavian knuckling syndrome’ in a riding stable in southern Finland.
Methods: Clinical neurological examination of 4 cases and neuropathological assessment of tissues of one case were performed.
Results: Eleven out of 17 horses fed on ryegrass from a common source showed progressive clinical signs of metatarsophalangeal extensor paresis necessitating euthanasia of 7 horses. Nervous system lesions in one horse consisted of a novel demyelinating, mildly inflammatory peripheral neuropathy, with BiP/GRP positive rough endoplasmatic reticulum Schwann cell inclusions.
Conclusions: The clinical signs and lesions documented differ from any previously described equine polyneuropathy and suggest a primary Schwann cell lesion.
Potential relevance: The classification of this disease as a novel demyelinating polyneuropathy may assist focused epidemiological investigations.