• Open Access

Scientific Opinion on the safety and efficacy of pantothenic acid (calcium D-pantothenate and D-panthenol) as a feed additive for all animal species based on a dossier submitted by Lohmann Animal Health


  • EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

  • Panel members: Gabriele Aquilina, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Joop de Knecht, Noël Dierick, Mikolaj Antoni Gralak, Jürgen Gropp, Ingrid Halle, Christer Hogstrand, Reinhard Kroker, Lubomir Leng, Anne-Katrine Lundebye Haldorsen, Secundino Lopez Puente, Alberto Mantovani, Giovanna Martelli, Miklós Mézes, Derek Renshaw, Maria Saarela, Kristen Sejrsen, Johannes Westendorf
  • Correspondence: feedap@efsa.europa.eu
  • Acknowledgement: The Panel wishes to thank the members of the Working Group on Vitamins, including Annette Schuhmacher, for the preparatory work on this scientific opinion.
  • Adoption date: 11 October 2011
  • Published date: 3 November 2011
  • Question number: EFSA-Q-2011-00256
  • On request from: European Commission


The use of calcium D-pantothenate in feed and of D-panthenol in water for drinking is safe for all animal species and categories. The use of calcium D-pantothenate and D-panthenol as nutritional additives does not give rise to concern for consumers. Since no data on acute inhalation toxicity has been provided, inhalation of dust is considered as potentially hazardous. D-panthenol being currently only available in liquid preparations, the FEEDAP Panel does not anticipate any inhalation hazard. Because of the lack of data, calcium D-pantothenate is considered as a skin and eye irritant and a skin sensitiser. D-Panthenol is regarded as a skin and eye irritant in rabbits, and allergic rashes in humans have been reported following its topical use. A risk for the environment resulting from the use of pantothenic acid in animal nutrition is not foreseen. Due to its established nutritional role in domestic animals, calcium D-pantothenate is regarded as an effective source of pantothenic acid. D-Panthenol is considered a pro-vitamin essentially bioequivalent to pantothenic acid.