• Open Access

Guidance on the safety assessment of Enterococcus faecium in animal nutrition


  • EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

  • Panel members: Gabriele Aquilina, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Joop de Knecht, Noël Albert Dierick, Mikolaj Antoni Gralak, Jürgen Gropp, Ingrid Halle, Christer Hogstrand, Reinhard Kroker, Lubomir Leng, Secundino López Puente, Anne-Katrine Lundebye Haldorsen, Alberto Mantovani, Giovanna Martelli, Miklós Mézes, Derek Renshaw, Maria Saarela, Kristen Sejrsen and Johannes Westendorf
  • Correspondence: feedap@efsa.europa.eu
  • Acknowledgement: The Panel wishes to thank the members of the Working Group on Micro-organisms, including Atte von Wright, Barbara E. Murray, Willem van Schaik and Johannes Huebner, for the preparatory work on this scientific opinion.
  • Adoption date: 25 April 2012
  • Published date: 23 May 2012
  • Question number: EFSA-Q-2011-01173
  • On request from: EFSA


This Guidance document is intended to provide a method to identify Enterococcus faecium strains belonging to a sub-population of bacteria isolated from clinical specimens. Differentiation is based on susceptibility to ampicillin and the absence of three genetic markers associated with the clinical isolates. In the view of the FEEDAP Panel any strain of E. faecium demonstrating a resistance to ampicillin greater than 2 mg/L or possessing any of the three marker genes should not be used as a feed additive.