• Open Access

Scientific Opinion on the safety and efficacy of Coxiril® (diclazuril) as a feed additive for guinea fowl

Authors

  • EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)


  • Panel members: Gabriele Aquilina, Vasileios Bampidis, Maria De Lourdes Bastos, Lucio Guido Costa, Gerhard Flachowsky, Mikolaj Antoni Gralak, Christer Hogstrand, Lubomir Leng, Secundino López-Puente, Giovanna Martelli, Baltasar Mayo, Fernando Ramos, Derek Renshaw, Guido Rychen, Maria Saarela, Kristen Sejrsen, Patrick Van Beelen, Robert John Wallace and Johannes Westendorf.
  • Correspondence: feedap@efsa.europa.eu
  • Acknowledgement: The Panel wishes to thank the members of the Working Group on Coccidiostats and Histomonostats, including Georges Bories, Paul Brantom, Jürgen Gropp and Ingrid Halle, for the preparatory work on this scientific opinion.
  • Adoption date: 22 May 2014
  • Published date: 18 June 2014
  • Question number: EFSA-Q-2013-00522
  • On request from: European Commission

Abstract

Coxiril®, containing 0.5 % diclazuril, is intended for use in the control of coccidiosis in guinea fowl at concentrations between 0.8 and 1.2 mg diclazuril/kg complete feed. Since diclazuril from Coxiril® is considered safe for turkeys for fattening with a margin of safety of 12-fold the intended dose, this conclusion can be extrapolated to guinea fowl, which is a physiologically similar minor species. Diclazuril at a level of 1.2 mg/kg complete feed is therefore safe for guinea fowl. The safety for the consumer of diclazuril when used as a feed additive for chickens for fattening and turkeys for fattening has been established. The FEEDAP Panel proposed that the same Maximum Residue Limits (MRLs) be applied as established in chickens and turkeys for fattening. A withdrawal time is not considered necessary. In the absence of data on residues of diclazuril in eggs, no conclusion on the potential exposure of the consumer can be made. No specific safety concerns related to the user or the environment were identified in the opinions on Coxiril® for chickens and turkeys for fattening, and the same applies to the use of Coxiril® in guinea fowl, since the conditions of use are similar. Based on the results of one study, in which guinea fowl were artificially infected with Eimeria numidia and Eimeria grenieri, and considering the established efficacy of the additive at the proposed use level compared with other Eimeria species, the FEEDAP Panel concludes that 0.8 mg diclazuril/kg feed has the potential to control coccidiosis in guinea fowl.

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