Pulsatile gonadotropin releasing hormone (GnRH)—treatment for hypothalamic amenorrhoea causing infertility

Authors

  • Goran Skarln,

    1. Specialist Open-care Unit of Obstetrics and Gynecology, Uppsala and the Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden
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  • Mats Ahlgren

    Corresponding author
    1. Specialist Open-care Unit of Obstetrics and Gynecology, Uppsala and the Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden
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Department of Obstetrics and Gynecology Lurid University Hospital S-221 85, Lund, Sweden

Abstract

Thirty women with hypothalamic amenorrhoea and infertility were treated with pulsatile GnRH S.C. without monitoring with estradiol and ultrasonography. Ovulation rate per patient was 93%. Ovulation rate per cycle was 90%. Pregnancy rate per ovulatory cycle 30%8. Miscarriage rate 18.5%. 23 children were born including one set of twins. No serious side effects were recorded.

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