Laparoscopic instillation of hyperosmolar glucose vs. expectant management of tubal pregnancies with serum hCG≤2500 mlU/mL
Article first published online: 31 DEC 2010
1997 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Acta Obstetricia et Gynecologica Scandinavica
Volume 76, Issue 8, pages 797–800, August 1997
How to Cite
Lang, P. F. J., Mäkinen, J. I., Irjala, K. M. A., Rantala, M., Hönigl, W., Tamussino, K. and Haas, J. (1997), Laparoscopic instillation of hyperosmolar glucose vs. expectant management of tubal pregnancies with serum hCG≤2500 mlU/mL. Acta Obstetricia et Gynecologica Scandinavica, 76: 797–800. doi: 10.3109/00016349709024350
- Issue published online: 31 DEC 2010
- Article first published online: 31 DEC 2010
- ectopic pregnancy;
- expectant management;
- glucose installation;
- hCG levels;
- spontaneous reaction;
- tubal pregnancy
Objective. To compare expectant management with local instillation of 50% glucose solution for tubal pregnancies with a serum hCG level ≤2500 mlU/mL. Design. Prospective, non-randomized, comparative clinical study.
Setting. Two university departments.
Patients. One hundred and twenty-eight patients with laparoscopically-confirmed tubal pregnancy and serum hCG ≤2500 mlU/mL.
Interventions. Eighty patients in Graz were treated with laparoscopic instillation of 50% glucose solution and 48 patients in Turku were followed expectantly.
Main outcome measures. Resolution of hCG excretion, need for further interventions.
Results. Seventy-four of the 80 patients (92%) in the glucose group (32 of 33 with an initial hCG ≤250 mlU/mL and 42 of 47 with hCG 251-2500 mlU/mL) and 36 of 48 (75%) patients in the expectant group (19 of 23 with an initial hCG ≤250 mlU/mL and 17 of 25 with hCG 251-2500 mlU/mL) had resolution of the pregnancy with no further intervention (p=0.008, chi-square test, odds ratio 0.24).
Conclusions. Glucose instillation is superior to expectant management for patients with early tubal pregnancy.