Preterm birth and cerebral palsy
Predictive value of pregnancy complications, mode of delivery, and Apgar scores
Article first published online: 31 DEC 2010
1997 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Acta Obstetricia et Gynecologica Scandinavica
Volume 76, Issue 9, pages 843–848, September 1997
How to Cite
Topp, M., Langhoff-Roos, J. and Uldall, P. (1997), Preterm birth and cerebral palsy. Acta Obstetricia et Gynecologica Scandinavica, 76: 843–848. doi: 10.3109/00016349709024363
- Issue published online: 31 DEC 2010
- Article first published online: 31 DEC 2010
- Accepted I8 March, 1997
- Apgar score;
- cerebral palsy;
- mode of delivery;
- pregnancy complications;
- preterm birth
Background. Preterm infants are at 8 times higher risk than term infants for pre- and perinatal brain damage, resulting in cerebral palsy. In this paper we have analysed the influence of prenatal and birth-related risk factors on cerebral palsy in preterm infants.
Methods. In a register-based study, 175 preterm singleton infants with cerebral palsy, born in 1982-86, were compared with 687 controls matched by gestational age and year of birth.
Results. Statistically significant higher rates in cases were found in parity ≥3 (22% vs. 16%, p<0.05), Cesarean section (67% vs. 56%, p<0.01), and low Apgar scores at 1 minute (45% vs. 36%, p<0.05). By multivariate analyses, two variables remained statistically significant: parity ≥3 (adjusted OR=1.53 (95% CI 1.00-2.34), p<0.05) and Cesarean section (adjusted OR=1.57 (95% CI 1.07-2.32), p<0.05).
Conclusions. Pregnancy complications preceding preterm birth did not imply a higher risk of cerebral palsy. Delivery by Cesarean section was a prognostic factor for developing cerebral palsy, and the predictive value of Apgar scores was highly limited.