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Version of Record online: 20 OCT 2010
Copyright © 2010 American Cancer Society, Inc.
CA: A Cancer Journal for Clinicians
Volume 60, Issue 6, pages 351–375, 1 November/1 December 2010
How to Cite
Robertson, F. M., Bondy, M., Yang, W., Yamauchi, H., Wiggins, S., Kamrudin, S., Krishnamurthy, S., Le-Petross, H., Bidaut, L., Player, A. N., Barsky, S. H., Woodward, W. A., Buchholz, T., Lucci, A., Ueno, N. and Cristofanilli, M. (2010), Inflammatory Breast Cancer: The Disease, the Biology, the Treatment. CA: A Cancer Journal for Clinicians, 60: 351–375. doi: 10.3322/caac.20082
DISCLOSURES: The Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The State of Texas Grant for Rare and Aggressive Cancers, and American Airlines Susan G. Komen for the Cure Promise Grant KGO81287 provided support for this study.
- Issue online: 12 NOV 2010
- Version of Record online: 20 OCT 2010
Inflammatory breast cancer (IBC) is a rare and aggressive form of invasive breast cancer accounting for 2.5% of all breast cancer cases. It is characterized by rapid progression, local and distant metastases, younger age of onset, and lower overall survival compared with other breast cancers. Historically, IBC is a lethal disease with less than a 5% survival rate beyond 5 years when treated with surgery or radiation therapy. Because of its rarity, IBC is often misdiagnosed as mastitis or generalized dermatitis. This review examines IBC's unique clinical presentation, pathology, epidemiology, imaging, and biology and details current multidisciplinary management of the disease, which comprises systemic therapy, surgery, and radiation therapy. CA Cancer J Clin 2010. © 2010 American Cancer Society, Inc.