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Genetics, genomics, and cancer risk assessment†‡

State of the Art and Future Directions in the Era of Personalized Medicine

  1. Jeffrey N. Weitzel MD1,*,
  2. Kathleen R. Blazer EdD, MS, CGC2,
  3. Deborah J. MacDonald PhD, RN, APNG3,
  4. Julie O. Culver MS, CGC4,
  5. Kenneth Offit MD, MPH5,*

Article first published online: 19 AUG 2011

DOI: 10.3322/caac.20128

Issue

CA: A Cancer Journal for Clinicians

CA: A Cancer Journal for Clinicians

Volume 61, Issue 5, pages 327–359, September/October 2011

Additional Information

How to Cite

Weitzel, J. N., Blazer, K. R., MacDonald, D. J., Culver, J. O. and Offit, K. (2011), Genetics, genomics, and cancer risk assessment. CA: A Cancer Journal for Clinicians, 61: 327–359. doi: 10.3322/caac.20128

Author Information

  1. 1

    Division of Clinical Cancer Genetics, Department of Population Sciences, City of Hope, Duarte, CA

  2. 2

    Cancer Genetics Education Program, Division of Clinical Cancer Genetics, Department of Population Sciences, City of Hope, Duarte, CA

  3. 3

    Division of Clinical Cancer Genetics, Department of Population Sciences, City of Hope, Duarte, CA

  4. 4

    Cancer Screening & Prevention Program, Division of Clinical Cancer Genetics, Department of Population Sciences, City of Hope, Duarte, CA

  5. 5

    Clinical Genetics Service, Program in Cancer Control, Prevention, and Population Research, Memorial Sloan-Kettering Cancer Center, New York, NY

*Division of Clinical Cancer Genetics, City of Hope, 1500 East Duarte Rd, Duarte, CA 91010

  1. †

    DISCLOSURES: Supported in part by National Cancer Institute grant R25CA112486 and grant RC4CA153828 from the National Cancer Institute and the Office of the Director, National Institutes of Health to Jeffrey Weitzel and City of Hope, and also by support to Kenneth Offit from the Robert and Kate Niehaus Clinical Cancer Genetics Initiative, the Sharon Levine Corzine Fund at Memorial Sloan-Kettering Cancer Center, the Lymphoma Foundation, and the Esther and Hyman Rapport Philanthropic Trust.

  2. ‡

    We are grateful to Peter Thom, MS, for his help with designing Figure §; to Dr. Stephen Gruber for his critical reading of the article; and to Tracy Sulkin and Shawntel Payton for assistance with preparation of the article. We also thank participants in the City of Hope Community Cancer Genetics and Research Training Intensive Course (National Cancer Institute grant R25CA112486; PI: J.N.W.) for providing insights about the challenges and rewards of providing genetic cancer risk assessment in community-based practices and the Cancer Genetics Community of Practice.

Publication History

  1. Issue published online: 26 AUG 2011
  2. Article first published online: 19 AUG 2011

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