DISCLOSURES: Dr. Maitland was supported by K23CA124802.
Clinical trials in the era of personalized oncology†
Article first published online: 27 OCT 2011
Copyright © 2011 American Cancer Society, Inc.
CA: A Cancer Journal for Clinicians
Volume 61, Issue 6, pages 365–381, November/December 2011
How to Cite
Maitland, M. L. and Schilsky, R. L. (2011), Clinical trials in the era of personalized oncology. CA: A Cancer Journal for Clinicians, 61: 365–381. doi: 10.3322/caac.20135
- Issue published online: 15 NOV 2011
- Article first published online: 27 OCT 2011
The rapid pace of discoveries in tumor biology, imaging technology, and human genetics hold promise for an era of personalized oncology care. The successful development of a handful of new targeted agents has generated much hope and hype about the delivery of safer and more effective new treatments for cancer. The design and conduct of clinical trials has not yet adjusted to a new era of personalized oncology and so we are more in transition to that era than in it. With the development of treatments for breast cancer as a model, we review the approaches to clinical trials and the development of novel therapeutics in the prior era of population oncology, the current transitional era, and the future era of personalized oncology. CA Cancer J Clin 2011. © 2011 American Cancer Society.