Nanooncology: The future of cancer diagnosis and therapy

Authors

  • Avnesh S. Thakor MD, PhD,

    1. Visiting Research Scholar, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, CA
    2. Fellow in Interventional Radiology, University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada
    3. Academic Fellow, Department of Interventional Radiology, University of Cambridge, Cambridge, UK
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  • Sanjiv S. Gambhir MD, PhD

    Corresponding author
    1. Director, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, CA
    2. Chair, Department of Radiology, Professor, Departments of Bioengineering and Materials Science and Engineering, Stanford University, Stanford, CA
    • Corresponding author: Sanjiv S. Gambhir, MD, PhD, Chair, Department of Radiology, The James H. Clark Center, Stanford University School of Medicine, 318 Campus Dr, Stanford, CA 94305-5427; sgambhir@stanford.edu

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  • We would like to thank Jim Stommer for help with the preparation of the figures in this article.

  • DISCLOSURES: The authors report no conflicts of interest.

Abstract

In recent years, there has been an unprecedented expansion in the field of nanomedicine with the development of new nanoparticles for the diagnosis and treatment of cancer. Nanoparticles have unique biological properties given their small size and large surface area-to-volume ratio, which allows them to bind, absorb, and carry compounds such as small molecule drugs, DNA, RNA, proteins, and probes with high efficiency. Their tunable size, shape, and surface characteristics also enable them to have high stability, high carrier capacity, the ability to incorporate both hydrophilic and hydrophobic substances and compatibility with different administration routes, thereby making them highly attractive in many aspects of oncology. This review article will discuss how nanoparticles are able to function as carriers for chemotherapeutic drugs to increase their therapeutic index; how they can function as therapeutic agents in photodynamic, gene, and thermal therapy; and how nanoparticles can be used as molecular imaging agents to detect and monitor cancer progression. CA Cancer J Clin 2013;63:395-418. ©2013 American Cancer Society, Inc.

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