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Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and Treatment†
Article first published online: 23 FEB 2009
Copyright © 2001 American Cancer Society
CA: A Cancer Journal for Clinicians
Volume 51, Issue 5, pages 290–315, September/October 2001
How to Cite
Köstler, W. J., Hejna, M., Wenzel, C. and Zielinski, C. C. (2001), Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and Treatment. CA: A Cancer Journal for Clinicians, 51: 290–315. doi: 10.3322/canjclin.51.5.290
- Issue published online: 23 FEB 2009
- Article first published online: 23 FEB 2009
Chemotherapy- and radiotherapy-induced oral mucositis represents a therapeutic challenge frequently encountered in cancer patients. This side effect causes significant morbidity and may delay the treatment plan, as well as increase therapeutic expenses.
The pathogenesis of this debilitating side effect can be attributed to the direct mucosal toxicity of cytotoxic agents and ionizing radiation and to indirect mucosal damage caused by a concomitant inflammatory reaction exacerbated in the presence of neutropenia, and the emergence of bacterial, mycotic, and viral infections. The prophylactic and therapeutic armamentarium for the treatment of oral mucositis consists of locally and systemically applied nonpharmacological measures and pharmacotherapeutics.