American Cancer Society Guideline for Human Papillomavirus (HPV) Vaccine Use to Prevent Cervical Cancer and Its Precursors

Authors

  • Dr. Debbie Saslow PhD,

    1. Saslow is Director, Breast and Gynecologic Cancer, Cancer Control Science Department, American Cancer Society, Atlanta, GA
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  • Dr. Philip E. Castle PhD, MPH,

    1. Castle is Investigator, Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD
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  • Dr. J. Thomas Cox MD,

    1. Cox is Director, Colposcopy and Gynecologic Clinic, Health Services Department, University of California, Santa Barbara, CA
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  • Dr. Diane D. Davey MD,

    1. Davey is Professor, Department of Pathology and Laboratory Medicine; and Director, Cytopathology, University of Kentucky Medical Center, Lexington, KY
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  • Dr. Mark H. Einstein MD, MS,

    1. Einstein is Director, Clinical Research; and Attending Physician, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women's Health, Montefiore Medical Center, Bronx, NY
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  • Dr. Daron G. Ferris MD,

    1. Ferris is Director, Gynecologic Cancer Prevention Center; and Professor, Departments of Family Medicine and Obstetrics and Gynecology, Medical College of Georgia, Augusta, GA
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  • Dr. Sue J. Goldie MD, MPH,

    1. Goldie is Professor of Health Policy and Decision Science; and Director of the Program in Health Decision Science, Department of Health Policy and Management, Harvard School of Public Health, Boston, MA
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  • Dr. Diane M. Harper MD, MPH, MS,

    1. Harper is Professor, Dartmouth Medical School; and Director, Gynecologic Cancer Prevention Research Group, Norris Cotton Cancer Center, Hanover, NH
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  • Dr. Walter Kinney MD,

    1. Kinney is Gynecologic Oncologist, Division of Gynecologic Oncology, The Permanente Medical Group, Inc., Sacramento, CA; and Associate Clinical Professor of Obstetrics and Gynecology, University of California, Davis, CA
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  • Dr. Anna-Barbara Moscicki MD,

    1. Moscicki is Professor of Pediatrics; and Associate Director, Division of Adolescent Medicine, University of California, San Francisco, CA
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  • Dr. Kenneth L. Noller MD,

    1. Noller is Gynecologist-in-Chief, Tufts-New England Medical Center, Boston, MA
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  • Dr. Cosette M. Wheeler PhD,

    1. Wheeler is Professor, Departments of Molecular Genetics and Microbiology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM
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  • Ms. Terri Ades RN, MS, AOCN,

    1. Ades is Director, Cancer Information, Health Promotions Department, American Cancer Society, Atlanta, GA
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  • Ms. Kimberly S. Andrews,

    1. Andrews is Research Associate, Cancer Control Science Department, American Cancer Society, Atlanta, GA
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  • Ms. Mary K. Doroshenk MA,

    1. Doroshenk is Manager, National Colorectal Cancer Roundtable, Cancer Control Science Department, American Cancer Society, Washington, DC
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  • Kelly Green Kahn,

    1. Green Kahn is Senior Federal Relations Representative, National Government Relations Department, American Cancer Society, Washington, DC
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  • Ms. Christy Schmidt,

    1. Schmidt is Senior Director, Policy, National Government Relations Department, American Cancer Society, Washington, DC
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  • Dr. Omar Shafey PhD, MPH,

    1. Shafey is Director, International Programs and Research, International Affairs Department, American Cancer Society, Atlanta, GA
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  • Dr. Robert A. Smith PhD,

    1. Smith is Director, Cancer Screening, Cancer Control Science Department, American Cancer Society, Atlanta, GA
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  • Dr. Edward E. Partridge MD,

    1. Partridge is Acting Director of the Comprehensive Cancer Center; and Professor of Obstetrics and Gynecology, Division of Gynecologic Oncology, The University of Alabama at Birmingham, Birmingham, AL
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  • Dr. Francisco Garcia MD, MPH

    1. Garcia is Associate Professor of Obstetrics and Gynecology; and Director, University of Arizona National Center of Excellence in Women's Health and the Arizona Hispanic Center of Excellence, Tucson, AZ.
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  • This article is available online at http://CAonline.AmCancerSoc.org

  • To earn free CME credit for successfully completing the online quiz based on this article, go to http://CME.AmCancerSoc.org.

  • Disclosures: Workgroup members were asked to disclose relationships, including potential financial conflicts of interest, with vaccine manufacturers or trials. The following was disclosed: F. Garcia participated in an expert panel for GlaxoSmithKline (GSK) for an unrelated immune therapeutic class of agents; C. Cohen is a paid speaker for Merck; T. Cox is a paid member of the Merck Data Safety and Monitoring Committee and received an honorarium for serving on one management advisory board for GSK; D. Davey serves on the working group of the NCI-sponsored trial of GSK vaccine in Costa Rica; M. Einstein has received research support from GSK for a nonvaccine-related activity and serves on the speaker's bureau for Merck, but receives no salary support or honorarium; D. Ferris receives research support for vaccine trials from Merck and GSK and serves as a colposcopy quality control consultant to both Merck and GSK and on the Merck medical advisory board; D. Harper serves on the study planning committee for Merck and GSK and is a clinical site PI for GSK; A. Moscicki serves on Merck's speaker's bureau and adolescent advisory board and is a local PI on the GSK vaccine trial; E. Partridge received an honorarium for a one-day advisory meeting for Merck and is a PI for a clinical study site for Merck; C. Wheeler receives research support for vaccine trials from Merck and GSK; D. Solomon is a medical monitor for the NCI-sponsored trial of GSK vaccine in Costa Rica.

Abstract

The American Cancer Society (ACS) has developed guidelines for the use of the prophylactic human papillomavirus (HPV) vaccine for the prevention of cervical intraepithelial neoplasia and cervical cancer. These recommendations are based on a formal review of the available evidence. They address the use of prophylactic HPV vaccines, including who should be vaccinated and at what age, as well as a summary of policy and implementation issues. Implications for screening are also discussed.

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