Diagnostic Value of Contrast-Enhanced Sonography for Differentiation of Breast Lesions

A Meta-analysis

Authors

  • Ma Xuelei MD,

    Corresponding author
    1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
    2. Department of Oncology, West China Hospital, Sichuan University, Chengdu, China
    3. Collaborative Innovation Center for Biotherapy, Chengdu, China
    • Address correspondence to Xuelei Ma, MD, West China Hospital, 37 Guoxue Alley, 610041 Chengdu, China.

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  • Liu Rongjun MS,

    1. West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China
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  • Zhu Chenjing MD,

    1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
    2. Collaborative Innovation Center for Biotherapy, Chengdu, China
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  • Zhang Jing MD,

    1. West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China
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  • Ling Wenwu MD

    1. Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, China
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  • Xuelei Ma, Rongjun Liu, and Chenjing Zhu contributed equally to this work.

Abstract

Objectives

The purpose of this study was to systematically review and evaluate the diagnostic accuracy of contrast-enhanced sonography in the differential diagnosis of benign and malignant breast lesions.

Methods

The scientific literature databases PubMed and Embase were comprehensively searched for relevant studies before January 2015. Data were pooled to yield the summary sensitivity, specificity, and diagnostic odds ratio using meta-analysis software.

Results

A total of 29 studies with 2296 lesions were included in the analysis. The pooled sensitivity and specificity were 0.88 (95% confidence interval [CI], 0.86–0.90; inconsistency index [I2] = 77.9%) and 0.80 (95% CI, 0.78–0.83; I2 = 84.0%), respectively. The pooled diagnostic odds ratio was 30.35 (95% CI, 15.75–58.48; I2= 82.1%), and the area under the summary receiver operating characteristic curve was 0.9115 (SE, 0.0243).

Conclusions

The comprehensive results suggest that contrast-enhanced sonography could be a potentially effective method for differential diagnosis of benign and malignant breast lesions.

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