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Karla S. Brammer, Hyunsu Kim, Kunbae Noh, Mariana Loya, Christine J. Frandsen, Li-han Chen, Laura S. Connelly and Sungho Jin Highly Bioactive 8 nm Hydrothermal TiO2 Nanotubes Elicit Enhanced Bone Cell Response Advanced Engineering Materials 13

Article first published online: 17 JAN 2011 | DOI: 10.1002/adem.201080103

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Although there is a broad scope as regard to application, Ti orthopedic implants are just one class of medical devices that could benefit from a modified, nanostructured oxide surface. We have utilized a hydrothermal process to refine the TiO2 structure to an 8nm diameter nanotube geometry and evaluated its effect on bone cell growth. Although many properties and functions of the hydrothermally processed nanotubes have been evaluated, this is the first study to our knowledge on the biological responses to such ultrafine Ti oxide nanotube surfaces.

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