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Sebastian Grade, Jörg Eberhard, Philipp Wagener, Andreas Winkel, Csaba Laszlo Sajti, Stephan Barcikowski and Meike Stiesch Therapeutic Window of Ligand-Free Silver Nanoparticles in Agar-Embedded and Colloidal State: In Vitro Bactericidal Effects and Cytotoxicity Advanced Engineering Materials 14

Version of Record online: 8 MAY 2012 | DOI: 10.1002/adem.201180016

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Laser-generated ligand-free silver nanoparticles (AgNPs) were tested on their bactericidal and cellular effects using a colloidal and matrix-embedded in vitro model. Significant antimicrobial effects of AgNPs against different bacteria relevant in medicine were observed, accompanied by minimal cytotoxic effects. This indicates a therapeutic window for antibacterial purposes of these AgNPs in medicine.

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