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Vinayaraj Ozhukil Kollath, Bruno G. De Geest, Steven Mullens, Stefaan De Koker, Jan Luyten, Rosita Persoons, Karl Traina, Jean Paul Remon and Rudi Cloots Systematic Processing of β-Tricalcium Phosphate for Efficient Protein Loading and In Vitro Analysis of Antigen Uptake Advanced Engineering Materials 15

Version of Record online: 22 NOV 2012 | DOI: 10.1002/adem.201200177

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For the application of oral vaccination, biodegradable protein carriers are required. This study optimizes a powder processing route to increase the protein loading on β-tricalcium phosphate powder to be used as protein carrier. Linear correlation between apparent external surface area of the powder and adsorption efficiency is observed. Dendritic cell uptake showed the biocompatibility of the system to be capable as antigen carrier to these cells.

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