C. Picart, A. Schneider, O. Etienne, J. Mutterer, P. Schaaf, C. Egles, N. Jessel and J.-C. Voegel Controlled Degradability of Polysaccharide Multilayer Films In Vitro and In Vivo Advanced Functional Materials 15
Polysaccharide multilayer film degradation can be tuned via control of film crosslinking and component molecular weight. Studies performed in vitro and in vivo confirm that films of chitosan/hyaluronan layers are more resistant to enzymatic and macrophage degradation when crosslinked (see Figure: right panel, increased crosslinking, scale bar 110 μm) or formed with medium-molecular-weight chitosan. Applications as biodegradable coatings are envisaged.
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