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M. Dimitrova, Y. Arntz, P. Lavalle, F. Meyer, M. Wolf, C. Schuster, Y. Haïkel, J.-C. Voegel and J. Ogier Adenoviral Gene Delivery from Multilayered Polyelectrolyte Architectures Advanced Functional Materials 17

Article first published online: 19 DEC 2006 | DOI: 10.1002/adfm.200600155

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A bioactive adenoviral vector is embedded into multilayered polyelectrolyte films. Ad efficiently adsorbs on poly(L-lysine)–poly(L-glutamic acid), poly(L-lysine)–hyaluronan, poly(allylamin hydrochloride)–poly(sodium-4-styrenesulfonate) (see the AFM image), and chitosan–hyaluronan films, and preserves its transduction capacity for a large number of cell types.

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