Kefeng Ren, Thomas Crouzier, Christian Roy and Catherine Picart Polyelectrolyte Multilayer Films of Controlled Stiffness Modulate Myoblast Cell Differentiation Advanced Functional Materials 18
Multilayer films made of poly(L-lysine)/hyaluronan (PLL/HA) of controlled stiffness have been used to investigate the effects of the mechanical properties of thin films on skeletal muscle cell (C2C12 cells) differentiation. The film stiffness strongly modulates not only initial myoblast adhesion and proliferation, but also myoblast differentiation into myotubes. On soft films, myotubes are initially short and thick before clumping and detaching. On stiff films, cells form elongated and thin striated myotubes.
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