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Paritosh P. Wattamwar, Yiqun Mo, Rong Wan, Roshan Palli, Qunwei Zhang and Thomas D. Dziubla Antioxidant Activity of Degradable Polymer Poly(trolox ester) to Suppress Oxidative Stress Injury in the Cells Advanced Functional Materials 20

Version of Record online: 18 NOV 2009 | DOI: 10.1002/adfm.200900839

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A therapeutic antioxidant polymer, poly- (trolox) (PTx), is synthesized by esterification of trolox, a synthetic water-soluble analogue of Vitamin E. PTx nanoparticles (NPs) have very little to no cytotoxicity and can protect cells from metal-nanoparticle (Nano Co)-induced oxidative injury. In vitro studies suggest that PTx nanoparticles undergo enzyme-mediated degradation, which releases the active antioxidants.

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