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Hsi-Chin Wu, Tzu-Wei Wang, Martha C. Bohn, Feng-Huei Lin and Myron Spector Novel Magnetic Hydroxyapatite Nanoparticles as Non-Viral Vectors for the Glial Cell Line-Derived Neurotrophic Factor Gene Advanced Functional Materials 20

Article first published online: 9 NOV 2009 | DOI: 10.1002/adfm.200901108

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Magnetic synthetic hydroxyapatite and natural bone mineral nanoparticles are synthesized as non-viral vectors for gene delivery. The magnetic calcium phosphate nanoparticles display a high binding affinity for plasmid DNA in contrast to magnetite nanoparticles and enable substantial increases in the transfection of mesenchymal stem cells in vitro with the gene for a neurotrophic factor, under the action of an external magnet.

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