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Leticia Hosta-Rigau, Brigitte Städler, Yan Yan, Edouard Collins Nice, Joan K. Heath, Fernando Albericio and Frank Caruso Capsosomes with Multilayered Subcompartments: Assembly and Loading with Hydrophobic Cargo Advanced Functional Materials 20

Version of Record online: 26 OCT 2009 | DOI: 10.1002/adfm.200901297

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Capsosomes, polymer capsules containing liposomes, are engineered to contain multiple liposome layers, thus providing a means to tune liposome loading. Drug-loaded capsosomes are formed by entrapping the antitumor hydrophobic peptide thiocoraline within the lipid membrane of the liposomal subcompartments. The drug-loaded capsosomes show anti-tumor activity, as verified by a cell viability assay using a cancer cell line.

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