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Jiankang He, Yanan Du, José L. Villa-Uribe, Changmo Hwang, Dichen Li and Ali Khademhosseini Rapid Generation of Biologically Relevant Hydrogels Containing Long-Range Chemical Gradients Advanced Functional Materials 20

Article first published online: 24 NOV 2009 | DOI: 10.1002/adfm.200901311

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A simple fluidic-based approach for rapidly engineering materials containing centimeter-long gradients of chemical properties is demonstrated. As an example, a gradient poly(ethylene glycol)- diacrylate (PEG-DA) hydrogel fabricated in a microfluidic channel with continuous variance in thickness (after air-drying) or porosity (after freeze-drying) is shown (see figure).

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