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Happy Tan, Jun Min Xue, Borys Shuter, Xu Li and John Wang Synthesis of PEOlated Fe3O4@SiO2 Nanoparticles via Bioinspired Silification for Magnetic Resonance Imaging Advanced Functional Materials 20

Version of Record online: 1 FEB 2010 | DOI: 10.1002/adfm.200901820

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A bioinspired silification strategy is developed to prepare Fe3O4@SiO2 nanoparticles, instrinsically being covered by a layer of free poly(ethylene oxide) (PEO) chains on the surface. The resultant nanoparticles are highly stable not only in aqueous environment, but also in the presence of proteins under physiological conditions. These nanoparticles exhibit high transverse (r2) and low longitudinal (r1) relaxivities, making them efficient magnetic resonance contrast agents.

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