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Gregory A. Hudalla and William L. Murphy Biomaterials that Regulate Growth Factor Activity via Bioinspired Interactions Advanced Functional Materials 21

Article first published online: 29 APR 2011 | DOI: 10.1002/adfm.201002468

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In natural microenvironments, growth factor activity is regulated via noncovalent interactions with core extracellular matrix biomolecules, such as proteins and proteoglycans. These interactions have inspired the development of natural and synthetic biomaterials that can noncovalently regulate growth factor activity for tissue engineering applications. These biomaterials, and their efficacy in regenerating functional tissue, are the focus of this Feature Article.

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