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Dongmei Fan, Enrica De Rosa, Matthew B. Murphy, Yang Peng, Christine A. Smid, Ciro Chiappini, Xuewu Liu, Paul Simmons, Bradley K. Weiner, Mauro Ferrari and Ennio Tasciotti Mesoporous Silicon-PLGA Composite Microspheres for the Double Controlled Release of Biomolecules for Orthopedic Tissue Engineering Advanced Functional Materials 22

Article first published online: 19 OCT 2011 | DOI: 10.1002/adfm.201100403

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Poly(dl-lactide-co-glycolide)/porous silicon (PLGA/pSi) composite microspheres are synthesized by a solid-in-oil-in-water (S/O/W) emulsion method. These composite microspheres can exhibit sustained protein release, preserve protein bioactivity, stimulate mineralization, neutralize the acidic pH due to the PLGA degradation by-products, and avoid uptake by cells. These microspheres are developed for the long-term controlled delivery of biomolecules for orthopedic tissue engineering applications.

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