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Timo Lebold, Axel Schlossbauer, Katrin Schneider, Lothar Schermelleh, Heinrich Leonhardt, Thomas Bein and Christoph Bräuchle Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica Advanced Functional Materials 22

Article first published online: 24 OCT 2011 | DOI: 10.1002/adfm.201101365

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Template-free SBA-15 type mesoporous silica particles are loaded with siRNA and dsDNA. The particles’ uptake capability is controlled by an organic surface functionalization and the dynamics of the intact oligonucleotides inside the functionalized nanochannels determined. The study demonstrates the potential of mesoporous silica as an alternative means for gene delivery. Such alternatives are urgently needed since the delivery of oligonucleotides to their target sites still represents a major hurdle in the application of gene therapy.

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