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Ying-Chieh Chen, Ruei-Zeng Lin, Hao Qi, Yunzhi Yang, Hojae Bae, Juan M. Melero-Martin and Ali Khademhosseini Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels Advanced Functional Materials 22

Version of Record online: 21 FEB 2012 | DOI: 10.1002/adfm.201101662

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Using gelatin methacrylate (GelMA) hydrogel as the embedding scaffold, 3D constructs containing human-blood-derived endothelial colony-forming cells (ECFCs) and bone marrow-derived mesenchymal stem cells (MSCs) are shown to generate extensive, functional capillary-like networks in vitro and in vivo. These data suggest that GelMA hydrogels can be used for biomedical applications requiring the formation of microvascular networks, including development of complex engineered tissues.

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