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Zheng Qu, Sharmila Muthukrishnan, Murali K. Urlam, Carolyn A. Haller, Sumanas W. Jordan, Vivek A. Kumar, Ulla M. Marzec, Yaseen Elkasabi, Joerg Lahann, Stephen R. Hanson and Elliot L. Chaikof A Biologically Active Surface Enzyme Assembly that Attenuates Thrombus Formation Advanced Functional Materials 21

Version of Record online: 26 SEP 2011 | DOI: 10.1002/adfm.201101687

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A biologically active thrombomodulin surface assembly to limit interfacial thrombin production was generated on the lumen of clinical ePTFE vascular grafts by site-specific covalent immobilization. Therapeutic capacity of this biomimetic surface engineering approach to attenuate thrombus formation was demonstrated in a clinically relevant in vivo model of prosthetic graft thrombosis.

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