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Gaomai Yang, Libing Liu, Qiong Yang, Fengting Lv and Shu Wang A Multifunctional Cationic Pentathiophene: Synthesis, Organelle-Selective Imaging, and Anticancer Activity Advanced Functional Materials 22

Version of Record online: 13 DEC 2011 | DOI: 10.1002/adfm.201101764

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A cationic pentathiophene (5T) is synthesized and discovered with both anticancer activity and molecular imaging properties. 5T can selectively accumulate in mitochondria to exhibit organellar imaging and efficiently induce cell apoptosis associating with c-jun N-terminal kinase (JNK) JNK pathway activation. The 5T-chlorambucil nanoparticles enhance anticancer activity by 2 to 9 fold due to the synergistical anticancer activity of 5T and chlorambucil.

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