Konstantinos Tsioris, Waseem K. Raja, Eleanor M. Pritchard, Bruce Panilaitis, David L. Kaplan and Fiorenzo G. Omenetto Fabrication of Silk Microneedles for Controlled-Release Drug Delivery Advanced Functional Materials 22
A fabrication method to produce silk biopolymer microstructures with the high aspect ratios required to manufacture microneedle systems is reported. Room temperature and aqueous-based micromolding allows for the bulk loading of these microneedles with sensitive drugs. Controlled release of a model drug is achieved by adjusting the post-processing conditions of the microneedles, mainly by controlling the silk protein secondary structure.
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