Jeong Heon Lee, Hoon Hyun, Conor J. Cross, Maged Henary, Khaled A. Nasr, Rafiou Oketokoun, Hak Soo Choi and John V. Frangioni Rapid and Facile Microwave-Assisted Surface Chemistry for Functionalized Microarray Slides Advanced Functional Materials 22
Microwave-assisted surface funcationlization and ligand imprinting using an automated robotic chemistry system for high-throughput live cell screening is developed. Using microwave irradiation, complete silanization and PEGylation are obtained in 18.4 min, which was characterized by water contact angle and fluorescence measurements. Cell binding ligands are incorporated into 300-μm circular spots providing adequate space for up to 230 living cell interactions.
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