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Wei Qin, Dan Ding, Jianzhao Liu, Wang Zhang Yuan, Yong Hu, Bin Liu and Ben Zhong Tang Biocompatible Nanoparticles with Aggregation-Induced Emission Characteristics as Far-Red/Near-Infrared Fluorescent Bioprobes for In Vitro and In Vivo Imaging Applications Advanced Functional Materials 22

Article first published online: 9 DEC 2011 | DOI: 10.1002/adfm.201102191

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Encapsulation of far-red/near-infrared luminogens with aggregation-induced emission (AIE) characteristics in a bovine serum albumin (BSA) matrix yields nanoparticles (NPs) with uniform size, high brightness, and low cytotoxicity. Applications of these AIE-active NPs for in vitro and in vivo fluorescence imaging are demonstrated using MCF-7 breast-cancer cells and a murine hepatic H22-tumor-bearing mouse model, respectively.

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