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Wei Yuan, Chunyan Li, Chen Zhao, Chenguang Sui, Wan-Tai Yang, Fu-Jian Xu and Jie Ma Facilitation of Gene Transfection and Cell Adhesion by Gelatin-Functionalized PCL Film Surfaces Advanced Functional Materials 22

Version of Record online: 8 FEB 2012 | DOI: 10.1002/adfm.201102221

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Efficient local gene transfection on a tissue scaffold is of crucial importance in facilitating tissue repair and regeneration. The gelatin-functionalized polycaprolactone (PCL) film surfaces are prepared via surface-initiated atom transfer radical polymerization (ATRP) of glycidyl methacrylate (GMA), which could enhance the cell-adhesion and local gene transfection properties. With the pre- and post-loading sandwich-like gene transfection, the gelatin-functionalized PCL film surface can substantially enhance the transfection properties to different cell lines.

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